Article
Comprehensive characterization of mesenchymal stromal cells from patients with Fanconi anaemia.
British journal of haematology - 1 Sept 2015
Mantelli Melissa, Avanzini Maria Antonia, Rosti Vittorio, Ingo Daniela M, Conforti Antonella, Novara Francesca, Arrigo Giulia, Boni Marina, Zappatore Rita, Lenta Elisa, Moretta Antonia, Acquafredda Gloria, de Silvestri Annalisa, Cirillo Valentina, Cicchetti Elisa, Algeri Mattia, Strocchio Luisa, Vinti Luciana, Starc Nadia, Biagini Simone, Sirleto Pietro, Bernasconi Paolo, Zuffardi Orsetta, Maserati Emanuela, Maccario Rita, Zecca Marco, Locatelli Franco, Bernardo Maria Ester
Abstract excerpt
Fanconi anaemia (FA) is an inherited disorder characterized by pancytopenia, congenital malformations and a predisposition to develop malignancies. Alterations in the haematopoietic microenvironment of FA patients have been reported, but little is known regarding the components of their bone marrow (BM) stroma. We characterized mesenchymal stromal cells (MSCs) isolated from BM of 18 FA patients both before and...
Topics
- Antigens, Surface
- Case-Control Studies
- Cell Culture Techniques
- Cell Cycle
- Cell Differentiation
- Cell Proliferation
- Cellular Senescence