Article
TERT promoter mutations in melanoma render TERT expression dependent on MAPK pathway activation.
Oncotarget - 16 Aug 2016
Vallarelli Andrelou F, Rachakonda P Sivaramakrishna, André Jocelyne, Heidenreich Barbara, Riffaud Laurence, Bensussan Armand, Kumar Rajiv, Dumaz Nicolas
Abstract excerpt
The mechanism of telomerase re-activation in cancer had remained elusive until the discovery of frequent mutations in the promoter of the TERT gene that encodes the catalytic reverse transcriptase subunit of telomerase. We investigated the regulation of TERT expression in melanoma cell lines and our results show that promoter mutations render TERT expression dependent on MAPK activation due to oncogenic BRAF or...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.