Article
Core promoter STRs: novel mechanism for inter-individual variation in gene expression in humans.
Gene - 15 Jan 2012
Heidari A, Nariman Saleh Fam Z, Esmaeilzadeh-Gharehdaghi E, Banan M, Hosseinkhani S, Mohammadparast S, Oladnabi M, Ebrahimpour M R, Soosanabadi M, Farokhashtiani T, Darvish H, Firouzabadi S Ghasemi, Farashi S, Najmabadi H, Ohadi M
Abstract excerpt
In a genome-scale analysis of the composition of core promoter sequences, we have recently shown that approximately 25% of the human protein-coding genes have at least one short tandem repeat (STR) of 3-repeats in their core promoters (i.e. the interval between -120 to +1). Through their nucleosome processing effect, GA-repeats play a crucial role in the regulation of gene transcription. In this study, we chose...
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