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Article

Beneficial effects of rapamycin in a Drosophila model for hereditary spastic paraplegia.

Journal of cell science - 15 Jan 2017

Xu Shiyu, Stern Michael, McNew James A

Abstract excerpt

The locomotor deficits in the group of diseases referred to as hereditary spastic paraplegia (HSP) reflect degeneration of upper motor neurons, but the mechanisms underlying this neurodegeneration are unknown. We established a Drosophila model for HSP, atlastin (atl), which encodes an ER fusion protein. Here, we show that neuronal atl loss causes degeneration of specific thoracic muscles that is preceded by other...

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Identifiers

PMID: 27909242
DOI: 10.1242/jcs.196741
PMCID: PMC5278673

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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