Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Drosophila Atlastin regulates the stability of muscle microtubules and is required for synapse development.

Developmental biology - 15 Jun 2009

Lee Mihye, Paik Sang Kyoo, Lee Min-Jung, Kim Yoon-Jung, Kim Sungdae, Nahm Minyeop, Oh Soo-Jin, Kim Hyun-Man, Yim Jeongbin, Lee C Justin, Bae Yong Chul, Lee Seungbok

Abstract excerpt

Hereditary spastic paraplegia (HSP) is an inherited neurological disorder characterized by progressive spasticity and weakness of the lower extremities. The most common early-onset form of HSP is caused by mutations in the human gene that encodes the dynamin-family GTPase Atlastin-1 (Atl-1). Recently, loss of the Drosophila ortholog of Atl-1 (Atl) has been found to induce locomotor impairments from the earliest...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Drosophila melanogaster
Share to Drosophila Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Microtubules

Share to Morphogenesis

Share to Muscles

Share to Mutation

Share to Synapses

Source

Identifiers

PMID: 19341724
DOI: 10.1016/j.ydbio.2009.03.019

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Drosophila Atlastin regulates the stability of muscle microtubules and is required for synapse development.PMID 19341724Read ↗

<i>Drosophila</i> Atlastin regulates synaptic vesicle mobilization independent of Bone Morphogenetic Protein signalingSemantic proximity Read ↗

Identification of atlastin genetic modifiers in a model of hereditary spastic paraplegia in Drosophila.Semantic proximity Read ↗

Drosophila spastin regulates synaptic microtubule networks and is required for normal motor function.Semantic proximity Read ↗

Pharmacologic rescue of axon growth defects in a human iPSC model of hereditary spastic paraplegia SPG3A.Semantic proximity Read ↗

Disease-related phenotypes in a Drosophila model of hereditary spastic paraplegia are ameliorated by treatment with vinblastine.Semantic proximity Read ↗

Normal dynactin complex function during synapse growth in Drosophila requires membrane binding by Arfaptin.Semantic proximity Read ↗

Mutation-specific cellular mechanisms in Drosophila models of ATL1-associated hereditary spastic paraplegia.Semantic proximity Read ↗

Mammalian knock out cells reveal prominent roles for atlastin GTPases in ER network morphology.Semantic proximity Read ↗

Spastin, atlastin, and ER relocalization are involved in axon but not dendrite regeneration.Semantic proximity Read ↗

Atlastin-1 regulates endosomal tubulation and lysosomal proteolysis in human cortical neuronsSemantic proximity Read ↗

Atlastin-1 regulates endosomal tubulation and lysosomal proteolysis in human cortical neuronsSemantic proximity Read ↗

Novel insights into SMALED2: BICD2 mutations increase microtubule stability and cause defects in axonal and NMJ development.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.