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Article

MicroRNA-146a Induces Lineage-Negative Bone Marrow Cell Apoptosis and Senescence by Targeting Polo-Like Kinase 2 Expression.

Arteriosclerosis, thrombosis, and vascular biology - 1 Feb 2017

Deng Shanming, Wang Huilan, Jia Chunling, Zhu Shoukang, Chu Xianming, Ma Qi, Wei Jianqin, Chen Emily, Zhu Wei, Macon Conrad J, Jayaweera Dushyantha T, Dykxhoorn Derek M, Dong Chunming

Abstract excerpt

OBJECTIVE: Lineage-negative bone marrow cells (lin- BMCs) are enriched in endothelial progenitor cells and mediate vascular repair. Aging-associated senescence and apoptosis result in reduced number and functionality of lin- BMCs, impairing their prorepair capacity. The molecular mechanisms underlying lin- BMC senescence and apoptosis are poorly understood. MicroRNAs (miRNAs) regulate many important biological...

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Identifiers

PMID: 27908889
DOI: 10.1161/ATVBAHA.116.308378
PMCID: PMC5336135

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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