Article
Autosomal genetic control of human gene expression does not differ across the sexes.
Genome biology - 1 Dec 2016
Kassam Irfahan, Lloyd-Jones Luke, Holloway Alexander, Small Kerrin S, Zeng Biao, Bakshi Andrew, Metspalu Andres, Gibson Greg, Spector Tim D, Esko Tonu, Montgomery Grant W, Powell Joseph E, Yang Jian, Visscher Peter M, McRae Allan F
Abstract excerpt
BACKGROUND: Despite their nearly identical genomes, males and females differ in risk, incidence, prevalence, severity and age-at-onset of many diseases. Sexual dimorphism is also seen in human autosomal gene expression, and has largely been explored by examining the contribution of genotype-by-sex interactions to variation in gene expression. RESULTS: In this study, we use data from a mixture of pedigree and...
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