Article
Integrative genomic analysis identifies ancestry-related expression quantitative trait loci on DNA polymerase β and supports the association of genetic ancestry with survival disparities in head and neck squamous cell carcinoma.
Cancer - 1 Mar 2017
Ramakodi Meganathan P, Devarajan Karthik, Blackman Elizabeth, Gibbs Denise, Luce Danièle, Deloumeaux Jacqueline, Duflo Suzy, Liu Jeffrey C, Mehra Ranee, Kulathinal Rob J, Ragin Camille C
Abstract excerpt
BACKGROUND: African Americans with head and neck squamous cell carcinoma (HNSCC) have a lower survival rate than whites. This study investigated the functional importance of ancestry-informative single-nucleotide polymorphisms (SNPs) in HNSCC and also examined the effect of functionally important genetic elements on racial disparities in HNSCC survival. METHODS: Ancestry-informative SNPs, RNA sequencing,...
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