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Article

The impact of genomic ancestry on tumor genomics in head and neck squamous cell carcinoma.

Cancer metastasis reviews - 30 Jan 2026

Ndahayo Madeleine, Saxena Anirudh, Thomas Hannah, Barry Kathryn Hughes, Gaykalova Daria A

Abstract excerpt

Head and neck squamous cell carcinoma (HNSCC) exhibits significant survival disparities by ancestry. This review explores how genetic ancestry shapes the clinical and molecular features of HNSCC, providing insights into the molecular mechanisms underlying these disparities. We reveal the variation in gene expression, mutations, copy number alterations, and DNA methylation patterns between ancestral groups. These...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41615498
DOI: 10.1007/s10555-026-10312-7
PMCID: PMC12915327

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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