Article

Identification of Distinct Heterogenic Subtypes and Molecular Signatures Associated With African Ancestry in Triple Negative Breast Cancer Using Quantified Genetic Ancestry Models in Admixed Race Populations

2020-04-12

Abstract excerpt

Triple negative breast cancers (TNBCs) are molecularly heterogeneous, and the link between their aggressiveness with African ancestry is not established. We investigated primary TNBCs for gene expression among self-reported race (SRR) groups of African American (AA, n=42) and European American (EA, n=33) women. Using The Cancer Genome Atlas (TCGA) approaches, we analyzed RNA sequencing data to measure changes in g...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e7ce1bfe-503b-5774-b9af-cb534aade1d6
DOI: 10.20944/preprints202004.0178.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Identification of Distinct Heterogenic Subtypes and Molecular Signatures Associated With African Ancestry in Triple Negative Breast Cancer Using Quantified Genetic Ancestry Models in Admixed Race PopulationsDOI 10.20944/preprints202004.0178.v1Read

African-Ancestry Associated Gene Expression Signatures and Pathways in Triple Negative Breast Cancer, a Comparison across Women of African DescentSemantic proximity Read

African Ancestry–Associated Gene Expression Profiles in Triple-Negative Breast Cancer Underlie Altered Tumor Biology and Clinical Outcome in Women of African DescentSemantic proximity Read

African ancestry and risk variants associated with triple-negative breast cancer susceptibility in African American women.Semantic proximity Read

Ancestry-associated transcriptomic profiles of breast cancer in patients of African, Arab, and European ancestrySemantic proximity Read

Molecular profiling of a real-world breast cancer cohort with genetically inferred ancestries reveals actionable tumor biology differences between European ancestry and African ancestry patient populations.Semantic proximity Read

Differential expression between African-ancestry and White patients diagnosed with Triple-Negative Breast Cancer: EGFR, Myc, Bcl2 and β-Catenin as ancestry-associated markersSemantic proximity Read

Mutational landscape of triple-negative breast cancer in African American women.Semantic proximity Read

Genetic susceptibility loci for subtypes of breast cancer in an African American population.Semantic proximity Read

Breast cancer disparities in outcomes; unmasking biological determinants associated with racial and genetic diversity.Semantic proximity Read

Differences in the mutational landscape of triple-negative breast cancer in African Americans and Caucasians.Semantic proximity Read

Comparison of Breast Cancer Molecular Features and Survival by African and European Ancestry in The Cancer Genome Atlas.Semantic proximity Read

Population-specific patterns in assessing molecular subtypes of young black females with triple-negative breast cancerSemantic proximity Read