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Cross-ancestral GWAS identifies 29 novel variants across Head and Neck Cancer subsites

2024-11-18

Abstract excerpt

In this multi-ancestry genome-wide association study (GWAS) and fine mapping study of head and neck squamous cell carcinoma (HNSCC) subsites, we analysed 19,073 cases and 38,857 controls and identified 29 independent novel loci. We provide robust evidence that a 3’ UTR variant in TP53 (rs78378222, T>G) confers a 40% reduction in odds of developing overall HNSCC. We further examine the gene-environment relationship...

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Literature Corpus work
1dda3489-de68-5f9a-9d23-0e54dc662991
DOI
10.1101/2024.11.18.24317473
Open publication

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Cross-ancestral GWAS identifies 29 novel variants across Head and Neck Cancer subsitesDOI 10.1101/2024.11.18.24317473
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