Article
The Effect of an Extreme and Prolonged Population Bottleneck on Patterns of Deleterious Variation: Insights from the Greenlandic Inuit.
Genetics - 1 Feb 2017
Pedersen Casper-Emil T, Lohmueller Kirk E, Grarup Niels, Bjerregaard Peter, Hansen Torben, Siegismund Hans R, Moltke Ida, Albrechtsen Anders
Abstract excerpt
The genetic consequences of population bottlenecks on patterns of deleterious genetic variation in human populations are of tremendous interest. Based on exome sequencing of 18 Greenlandic Inuit we show that the Inuit have undergone a severe ∼20,000-year-long bottleneck. This has led to a markedly more extreme distribution of allele frequencies than seen for any other human population tested to date, making the...
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