Article

Extreme distribution of deleterious variation in a historically small and isolated population - insights from the Greenlandic Inuit

2016-06-30

Abstract excerpt

The genetic consequences of a severe bottleneck on genetic load in humans are widely disputed. Based on exome sequencing of 18 Greenlandic Inuit we show that the Inuit have undergone a severe ~20,000 yearlong bottleneck. This has led to a markedly more extreme distribution of deleterious alleles than seen for any other human population. Compared to populations with much larger population sizes, we see an overall r...

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Literature Corpus work: 04ed3c16-1242-5e67-b8cf-46190e56885a
DOI: 10.1101/061440

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