Article
Metformin pharmacogenomics: a genome-wide association study to identify genetic and epigenetic biomarkers involved in metformin anticancer response using human lymphoblastoid cell lines.
Human molecular genetics - 1 Nov 2016
Niu Nifang, Liu Tongzheng, Cairns Junmei, Ly Reynold C, Tan Xianglin, Deng Min, Fridley Brooke L, Kalari Krishna R, Abo Ryan P, Jenkins Gregory, Batzler Anthony, Carlson Erin E, Barman Poulami, Moran Sebastian, Heyn Holger, Esteller Manel, Wang Liewei
Abstract excerpt
Metformin is currently considered as a promising anticancer agent in addition to its anti-diabetic effect. To better individualize metformin therapy and explore novel molecular mechanisms in cancer treatment, we conducted a pharmacogenomic study using 266 lymphoblastoid cell lines (LCLs). Metformin cytotoxicity assay was performed using the MTS assay. Genome-wide association (GWA) analyses were performed in LCLs...
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