Article
Full-length HIV-1 Gag determines protease inhibitor susceptibility within in vitro assays.
AIDS (London, England) - 17 Jul 2010
Gupta Ravindra K, Kohli Arinder, McCormick Adele L, Towers Greg J, Pillay Deenan, Parry Chris M
Abstract excerpt
OBJECTIVE: There is evidence that gag contributes to protease inhibitor susceptibility in treatment-experienced patients. Moreover, protease inhibitor resistance-associated mutations can arise in gag in the absence of protease mutations in vitro. We wished to assess the contribution of full-length Gag to protease inhibitor susceptibility in viruses unexposed to protease inhibitors, in particular from the most...
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