Article
Characterization of HCV NS3 Protease Variants in HCV/HIV-Coinfected Patients by Ultra-Deep Sequence Analysis: Relationship with Hepatic Fibrosis.
Journal of acquired immune deficiency syndromes (1999) - 1 Mar 2017
Abdel-Hameed Enass A, Rouster Susan D, Zhang Xiang, Chen Jing, Medvedovic Mario, Goodman Zachary D, Sherman Kenneth E
Abstract excerpt
BACKGROUND: Treatment of HCV/HIV coinfection is now largely based on utilization of direct acting agents. Pretreatment viral resistant-associated variants (RAVs) and host liver condition may affect the sustained virological response. In this study, we explored relative prevalence of protease resistance-associated mutations, the evolution of those RAVs after 12 weeks of pegylated interferon alfa exposure, and the...
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