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Article

Donor-derived exosomes

25 Nov 2016

Abstract excerpt

PURPOSE OF REVIEW: The passenger leukocyte hypothesis predicts that after transplantation, donor antigen-presenting cells (APCs) from the graft present donor MHC molecules to directly alloreactive T cells in lymphoid organs. However, in certain transplantation models, recent evidence contradicts this long-standing concept. New findings demonstrate that host, instead of donor, APCs play a prominent role in...

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PMID: 27898464
DOI: 10.1097/mot.0000000000000372

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