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Extracellular Vesicles and Immune Activation in Solid Organ Transplantation: The Impact of Immunosuppression

26 Mar 2025

Abstract excerpt

Recent advances in extracellular vesicle (EV) research in organ transplantation have highlighted the crucial role of donor-derived EVs in triggering alloimmune responses, ultimately contributing to transplant rejection. Following transplantation, EVs carrying donor major histocompatibility complex (MHC) molecules activate recipient antigen-presenting cells (APCs), initiating both alloreactive and regulatory...

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PMID: 40140222
DOI: 10.1007/s40259-025-00713-5

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