Modification of host dendritic cells by microchimerism-derived extracellular vesicles generates split tolerance

Abstract excerpt

Significance The induction of tolerance is still an ideal and largely unachieved goal in the transplantation and autoimmunity fields. Understanding natural allotolerance mechanisms could help realize this objective. In this study we found that maternal microchimerism generated “split” tolerance, stimulating classical alloreactivity (i.e., recognition of intact peptide/allo-MHC class II complexes by CD4 T cells),...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to CAR-T cell therapy research
• Share to Extracellular vesicles in disease
• Share to Immunotherapy and Immune Responses