Article
Novel MHC class I structures on exosomes.
Journal of immunology (Baltimore, Md. : 1950) - 1 Aug 2009
Lynch Sarah, Santos Susana G, Campbell Elaine C, Nimmo Ailish M S, Botting Catherine, Prescott Alan, Antoniou Antony N, Powis Simon J
Abstract excerpt
Exosomes are nanometer-sized vesicles released by a number of cell types including those of the immune system, and often contain numerous immune recognition molecules including MHC molecules. We demonstrate in this study that exosomes can display a significant proportion of their MHC class I (MHC I) content in the form of disulfide-linked MHC I dimers. These MHC I dimers can be detected after release from various...
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