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Article

Gene silencing through methylation: An epigenetic intervention on Alzheimer disease

7 Aug 2006

Abstract excerpt

Alzheimer disease (AD) is among the few diseases that may display high homocysteine (HCY) and low B12 and folate in blood. This observation has raised the suspect that amyloid-beta overproduction and accumulation, which may be the cause of the disease, could be due to the loss of epigenetic control in the expression of the genes involved in AbetaPP (amyloid-beta protein precursor) processing. We have shown, in...

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PMID: 16917149
DOI: 10.3233/jad-2006-9406

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