Polymerase ε (POLE) ultra-mutation in uterine tumors correlates with T lymphocyte infiltration and increased resistance to platinum-based chemotherapy in vitro.

doi:10.1016/j.ygyno.2016.11.023

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Article

Polymerase ε (POLE) ultra-mutation in uterine tumors correlates with T lymphocyte infiltration and increased resistance to platinum-based chemotherapy in vitro.

Gynecologic oncology - 1 Jan 2017

Bellone Stefania, Bignotti Eliana, Lonardi Silvia, Ferrari Francesca, Centritto Floriana, Masserdotti Alice, Pettinella Francesca, Black Jonathan, Menderes Gulden, Altwerger Gary, Hui Pei, Lopez Salvatore, de Haydu Christopher, Bonazzoli Elena, Predolini Federica, Zammataro Luca, Cocco Emiliano, Ferrari Federico, Ravaggi Antonella, Romani Chiara, Facchetti Fabio, Sartori Enrico, Odicino Franco E, Silasi Dan-Arin, Litkouhi Babak, Ratner Elena, Azodi Masoud, Schwartz Peter E, Santin Alessandro D

Abstract excerpt

OBJECTIVE: Up to 12% of all endometrial-carcinomas (EC) harbor DNA-polymerase-ε-(POLE) mutations. It is currently unknown whether the favorable prognosis of POLE-mutated EC is derived from their low metastatic capability, extraordinary number of somatic mutations thus imparting immunogenicity, or a high sensitivity to chemotherapy. METHODS: Polymerase-chain-reaction-amplification and Sanger-sequencing were used...

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Identifiers

PMID: 27894751
DOI: 10.1016/j.ygyno.2016.11.023
PMCID: PMC5183545

Genes

POLE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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