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Article

Polymerase ε (POLE) ultra-mutated tumors induce robust tumor-specific CD4+ T cell responses in endometrial cancer patients.

Gynecologic oncology - 1 Jul 2015

Bellone Stefania, Centritto Floriana, Black Jonathan, Schwab Carlton, English Diana, Cocco Emiliano, Lopez Salvatore, Bonazzoli Elena, Predolini Federica, Ferrari Francesca, Silasi Dan-Arin, Ratner Elena, Azodi Masoud, Schwartz Peter E, Santin Alessandro D

Abstract excerpt

OBJECTIVE: Around 7-10% of endometrial carcinomas are characterized by polymerase-ε-(POLE) exonuclease-domain-mutations, an ultra-mutated-phenotype and a favorable prognosis. It is currently unknown whether POLE ultra-mutated-tumors are more immunogenic when compared to the other groups of endometrial cancers. METHODS: We used autologous-dendritic-cells (DC) pulsed with whole-tumor-extracts to assess the level of...

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Share to CD4-Positive T-Lymphocytes
Share to Cell Line, Tumor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to DNA Polymerase II

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Share to Poly-ADP-Ribose Binding Proteins

Share to T-Lymphocytes, Cytotoxic

Source

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Identifiers

PMID: 25931171
DOI: 10.1016/j.ygyno.2015.04.027
PMCID: PMC4469551

Genes

POLE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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