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Article

A functional ATG16L1 (T300A) variant is associated with necrotizing enterocolitis in premature infants.

Pediatric research - 1 Apr 2017

Sampath Venkatesh, Bhandari Vineet, Berger Jessica, Merchant Daniel, Zhang Liyun, Ladd Mihoko, Menden Heather, Garland Jeffery, Ambalavanan Namasivayam, Mulrooney Neil, Quasney Michael, Dagle John, Lavoie Pascal M, Simpson Pippa, Dahmer Mary

Abstract excerpt

BACKGROUND: The genetic basis of dysfunctional immune responses in necrotizing enterocolitis (NEC) remains unknown. We hypothesized that variants in nucleotide binding and oligomerization domain (NOD)-like receptors (NLRs) and autophagy (ATG) genes modulate vulnerability to NEC. METHODS: We genotyped a multi-center cohort of premature infants with and without NEC for NOD1, NOD2, ATG16L1, CARD8, and NLRP3...

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Source

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Identifiers

PMID: 27893720
DOI: 10.1038/pr.2016.260
PMCID: PMC5714513

Genes

CARD8
NLRP3
NOD1
NOD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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