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Article

Somatic increase of CCT8 mimics proteostasis of human pluripotent stem cells and extends C. elegans lifespan.

Nature communications - 28 Nov 2016

Noormohammadi Alireza, Khodakarami Amirabbas, Gutierrez-Garcia Ricardo, Lee Hyun Ju, Koyuncu Seda, König Tim, Schindler Christina, Saez Isabel, Fatima Azra, Dieterich Christoph, Vilchez David

Abstract excerpt

Human embryonic stem cells can replicate indefinitely while maintaining their undifferentiated state and, therefore, are immortal in culture. This capacity may demand avoidance of any imbalance in protein homeostasis (proteostasis) that would otherwise compromise stem cell identity. Here we show that human pluripotent stem cells exhibit enhanced assembly of the TRiC/CCT complex, a chaperonin that facilitates the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27892468
DOI: 10.1038/ncomms13649
PMCID: PMC5133698

Genes

CCT8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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