Article

CCT and Cullin1 regulate the TORC1 pathway to promote dendritic arborization in health and disease

2023-08-02

Abstract excerpt

<h4>ABSTRACT</h4> The development of cell-type-specific dendritic arbors is integral to the proper functioning of neurons within their circuit networks. In this study, we examine the regulatory relationship between the cytosolic chaperonin CCT, key insulin pathway genes, and an E3 ubiquitin ligase (Cullin1) in homeostatic dendritic development. CCT loss of function (LOF) results in dendritic hypotrophy in Drosop...

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Literature Corpus work: 8fffc911-4926-58b0-b593-f03c960e581e
DOI: 10.1101/2023.07.31.551324

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