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Article

Innate immunity and inflammophagy: balancing the defence and immune homeostasis

26 Nov 2021

Abstract excerpt

Extensive crosstalk exists between autophagy and innate immune signalling pathways. The stimuli that induce pattern recognition receptor (PRR)-mediated innate immune signalling pathways, also upregulate autophagy. The purpose of this increased autophagy is to eliminate the stimuli and/or suppress the inflammatory pathways by targeted degradation of PRRs or intermediary proteins (termed 'inflammophagy'). By...

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PMID: 34826185
DOI: 10.1111/febs.16298

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