Fuzzy tandem repeats containing p53 response elements may define species-specific p53 target genes.

Abstract excerpt

Evolutionary forces that shape regulatory networks remain poorly understood. In mammals, the Rb pathway is a classic example of species-specific gene regulation, as a germline mutation in one Rb allele promotes retinoblastoma in humans, but not in mice. Here we show that p53 transactivates the Retinoblastoma-like 2 (Rbl2) gene to produce p130 in murine, but not human, cells. We found intronic fuzzy tandem repeats...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Fibroblasts
• Share to Introns