Significant HLA class I type associations with aromatic antiepileptic drug (AED)-induced SJS/TEN are different from those found for the same AED-induced DRESS in the Spanish population.

doi:10.1016/j.phrs.2016.11.027

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Article

Significant HLA class I type associations with aromatic antiepileptic drug (AED)-induced SJS/TEN are different from those found for the same AED-induced DRESS in the Spanish population.

Pharmacological research - 1 Jan 2017

Ramírez Elena, Bellón Teresa, Tong Hoi Y, Borobia Alberto M, de Abajo Francisco J, Lerma Victoria, Moreno Hidalgo Miguel A, Castañer José L, Cabañas Rosario, Fiandor Ana, González-Ramos Jessica, Herranz Pedro, Cachafeiro Lucía, González-Herrada Carlos, González Olga, Aramburu José A, Laosa Olga, Hernández Rafael, Carcas Antonio J, Frías Jesús

Abstract excerpt

Aromatic antiepileptic drugs (AEDs) are among the drugs most frequently involved in severe cutaneous adverse reactions (SCARs), such as Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and drug reactions with eosinophilia and systemic symptoms (DRESS). This study investigated the associations between the genetic polymorphisms of HLA class-I and AED-induced SCARs in the Spanish population. HLA...

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PMID: 27888155
DOI: 10.1016/j.phrs.2016.11.027

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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