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Article

A data-driven weighting scheme for multivariate phenotypic endpoints recapitulates zebrafish developmental cascades.

Toxicology and applied pharmacology - 1 Jan 2017

Zhang Guozhu, Roell Kyle R, Truong Lisa, Tanguay Robert L, Reif David M

Abstract excerpt

Zebrafish have become a key alternative model for studying health effects of environmental stressors, partly due to their genetic similarity to humans, fast generation time, and the efficiency of generating high-dimensional systematic data. Studies aiming to characterize adverse health effects in zebrafish typically include several phenotypic measurements (endpoints). While there is a solid biomedical basis for...

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Identifiers

PMID: 27884602
DOI: 10.1016/j.taap.2016.11.010
PMCID: PMC5224523

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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