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Article

Statistical analysis of multi-endpoint phenotypic screening increases sensitivity of planarian neurotoxicity testing.

Toxicological sciences : an official journal of the Society of Toxicology - 1 Nov 2025

Ireland Danielle, Word Laura J, Collins Eva-Maria S

Abstract excerpt

There is an urgent need for high-throughput screening (HTS) models to replace, refine, and/or reduce ("3Rs") vertebrate toxicity testing. Replacing in vivo animal studies is challenging for neurotoxicity and developmental neurotoxicity (DNT), where the functional relevancy of adverse outcomes needs to be assessed on the whole organism. We previously screened the NTP 87-compound library (NTP87), consisting of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40839344
DOI: 10.1093/toxsci/kfaf117
PMCID: PMC12404179

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