Article
Classification and prediction of toxicity of chemicals using an automated phenotypic profiling of Caenorhabditis elegans.
BMC pharmacology & toxicology - 18 Apr 2018
Gao Shan, Chen Weiyang, Zeng Yingxin, Jing Haiming, Zhang Nan, Flavel Matthew, Jois Markandeya, Han Jing-Dong J, Xian Bo, Li Guojun
Abstract excerpt
BACKGROUND: Traditional toxicological studies have relied heavily on various animal models to understand the effect of various compounds in a biological context. Considering the great cost, complexity and time involved in experiments using higher order organisms. Researchers have been exploring alternative models that avoid these disadvantages. One example of such a model is the nematode Caenorhabditis elegans....
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