Article

Analyzing high-throughput assay data to advance the rapid screening of environmental chemicals for human reproductive toxicity

2024-05-22

Abstract excerpt

While high-throughput (HTP) assays have been proposed as platforms to rapidly assess reproductive toxicity, there is currently a lack of established assays that specifically address germline development/function and fertility. We assessed the applicability domains of yeast ( S. cerevisiae) and nematode (C. elegans) HTP assays in toxicity screening of 124 environmental chemicals, determining their agreement in id...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: efac4526-c60c-5335-81ea-af687aa29642
DOI: 10.1101/2024.05.21.595187

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Analyzing high-throughput assay data to advance the rapid screening of environmental chemicals for human reproductive toxicityDOI 10.1101/2024.05.21.595187Read

Developmental Effects of the ToxCast™ Phase I and Phase II Chemicals in Caenorhabditis elegans and Corresponding Responses in Zebrafish, Rats, and RabbitsSemantic proximity Read

C. elegans toxicant responses vary among genetically diverse individualsSemantic proximity Read

A curated knowledgebase enabling a network perspective on endocrine disrupting chemicals and their biological systems-level perturbationsSemantic proximity Read

Assessing effects of germline exposure to environmental toxicants by high-throughput screening in C. elegansSemantic proximity Read

A Deep-Learning Approach for Identifying Prospective Chemical HazardsSemantic proximity Read

Assessment of Chemical Toxicity in Adult Drosophila MelanogasterSemantic proximity Read

Uncertainty-aware machine learning to predict non-cancer human toxicity for the global chemicals marketSemantic proximity Read

Classification and prediction of toxicity of chemicals using an automated phenotypic profiling of Caenorhabditis elegans.Semantic proximity Read

Phenotypic screening of the ToxCast chemical library to classify toxic and therapeutic mechanisms.Semantic proximity Read

Transcriptomic and phenotypic profiling in developing zebrafish exposed to thyroid hormone receptor agonists.Semantic proximity Read

Predictive Models of Prenatal Developmental Toxicity from ToxCast High-Throughput Screening DataSemantic proximity Read

From molecular descriptors to the developmental toxicity prediction of pesticides/veterinary drugs/bio-pesticides against zebrafish embryo: Dual computational toxicological approaches for prioritizationSemantic proximity Read