Article
Genome-wide association study identifies the SERPINB gene cluster as a susceptibility locus for food allergy.
Nature communications - 20 Oct 2017
Marenholz Ingo, Grosche Sarah, Kalb Birgit, Rüschendorf Franz, Blümchen Katharina, Schlags Rupert, Harandi Neda, Price Mareike, Hansen Gesine, Seidenberg Jürgen, Röblitz Holger, Yürek Songül, Tschirner Sebastian, Hong Xiumei, Wang Xiaobin, Homuth Georg, Schmidt Carsten O, Nöthen Markus M, Hübner Norbert, Niggemann Bodo, Beyer Kirsten, Lee Young-Ae
Abstract excerpt
Genetic factors and mechanisms underlying food allergy are largely unknown. Due to heterogeneity of symptoms a reliable diagnosis is often difficult to make. Here, we report a genome-wide association study on food allergy diagnosed by oral food challenge in 497 cases and 2387 controls. We identify five loci at genome-wide significance, the clade B serpin (SERPINB) gene cluster at 18q21.3, the cytokine gene...
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