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Article

Mechanisms and controversies in mutant Cul3-mediated familial hyperkalemic hypertension.

American journal of physiology. Renal physiology - 1 May 2018

Ferdaus Mohammed Z, McCormick James A

Abstract excerpt

Autosomal dominant mutations in cullin-3 ( Cul3) cause the most severe form of familial hyperkalemic hypertension (FHHt). Cul3 mutations cause skipping of exon 9, which results in an internal deletion of 57 amino acids from the CUL3 protein (CUL3-∆9). The precise mechanism by which this altered form of CUL3 causes FHHt is controversial. CUL3 is a member of the cullin-RING ubiquitin ligase family that mediates...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29361671
DOI: 10.1152/ajprenal.00593.2017
PMCID: PMC6031903

Genes

CUL3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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