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Article

In vitro replication highlights the mutability of prions.

Prion - 1 Jan 2000

Vanni Ilaria, Di Bari Michele Angelo, Pirisinu Laura, D'Agostino Claudia, Agrimi Umberto, Nonno Romolo

Abstract excerpt

Prions exist as strains, which are thought to reflect PrP(Sc) conformational variants. Prion strains can mutate and it has been proposed that prion mutability depends on an intrinsic heterogeneity of prion populations that would behave as quasispecies. We investigated in vitro prion mutability of 2 strains, by following PrP(Sc) variations of populations serially propagated in PMCA under constant environmental...

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Identifiers

PMID: 24618479
DOI: 10.4161/pri.28468
PMCID: PMC7030905

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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