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Article

A Zebrafish Model for a Human Myopathy Associated with Mutation of the Unconventional Myosin MYO18B

23 Nov 2016

Abstract excerpt

Myosin 18B is an unconventional myosin that has been implicated in tumor progression in humans. In addition, loss-of-function mutations of the MYO18B gene have recently been identified in several patients exhibiting symptoms of nemaline myopathy. In mouse, mutation of Myo18B results in early developmental arrest associated with cardiomyopathy, precluding analysis of its effects on skeletal muscle development. The...

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PMID: 27879346
DOI: 10.1534/genetics.116.192864

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