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Article

Knockdown of fast skeletal myosin-binding protein C in zebrafish results in a severe skeletal myopathy

28 Mar 2016

Abstract excerpt

Myosin-binding protein C (MyBPC) in the muscle sarcomere interacts with several contractile and structural proteins. Mutations in the cardiac isoform (MyBPC-3) in humans, or animal knockout, are associated with cardiomyopathy. Function of the fast skeletal isoform (MyBPC-2) in living muscles is less understood. This question was addressed using zebrafish models, combining gene expression data with functional...

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PMID: 27022191
DOI: 10.1085/jgp.201511452

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