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Article

A novel isoform of myosin 18A (Myo18Aγ) is an essential sarcomeric protein in mouse heart

9 Feb 2019

Abstract excerpt

Whereas myosin 18B (Myo18B) is known to be a critical sarcomeric protein, the function of myosin 18A (Myo18A) is unclear, although it has been implicated in cell motility and Golgi shape. Here, we show that homozygous deletion (homozygous tm1a, tm1b, or tm1d alleles) of Myo18a in mouse is embryonic lethal. Reminiscent of Myo18b , Myo18a was highly expressed in the embryo heart, and cardiac-restricted Myo18a...

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PMID: 30737279
DOI: 10.1074/jbc.ra118.004560

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