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Article

MicroRNA-3906 regulates fast muscle differentiation through modulating the target gene homer-1b in zebrafish embryos.

PloS one - 1 Jan 2013

Lin Cheng-Yung, Chen Jie-Shin, Loo Moo-Rung, Hsiao Chung-Ching, Chang Wen-Yen, Tsai Huai-Jen

Abstract excerpt

A microRNA, termed miR-In300 or miR-3906, suppresses the transcription of myf5 through silencing dickkopf-related protein 3 (dkk3r/dkk3a) during early development when myf5 is highly transcribed, but not at late stages when myf5 transcription is reduced. Moreover, after 24 hpf, when muscle cells are starting to differentiate, Dkk3a could not be detected in muscle tissue at 20 hpf. To explain these reversals, we...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23936160
DOI: 10.1371/journal.pone.0070187
PMCID: PMC3729524

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