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Article

Cardiomyopathy in zebrafish due to mutation in an alternatively spliced exon of titin.

Nature genetics - 1 Feb 2002

Xu Xiaolei, Meiler Steffen E, Zhong Tao P, Mohideen Manzoor, Crossley Dane A, Burggren Warren W, Fishman Mark C

Abstract excerpt

The zebrafish embryo is transparent and can tolerate absence of blood flow because its oxygen is delivered by diffusion rather than by the cardiovascular system. It is therefore possible to attribute cardiac failure directly to particular genes by ruling out the possibility that it is due to a secondary effect of hypoxia. We focus here on pickwickm171 (pikm171), a recessive lethal mutation discovered in a...

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Identifiers

PMID: 11788825
DOI: 10.1038/ng816

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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