Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A TALEN-Exon Skipping Design for a Bethlem Myopathy Model in Zebrafish.

PloS one - 1 Jan 2015

Radev Zlatko, Hermel Jean-Michel, Elipot Yannick, Bretaud Sandrine, Arnould Sylvain, Duchateau Philippe, Ruggiero Florence, Joly Jean-Stéphane, Sohm Frédéric

Abstract excerpt

Presently, human collagen VI-related diseases such as Ullrich congenital muscular dystrophy (UCMD) and Bethlem myopathy (BM) remain incurable, emphasizing the need to unravel their etiology and improve their treatments. In UCMD, symptom onset occurs early, and both diseases aggravate with ageing. In zebrafish fry, morpholinos reproduced early UCMD and BM symptoms but did not allow to study the late phenotype....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Collagen Type VI
Share to Contracture

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Disease Models, Animal

Share to Homozygote

Share to Muscular Dystrophies

Share to RNA Splice Sites

Share to Zebrafish

Source

Open in PubMed Open full text

Identifiers

PMID: 26221953
DOI: 10.1371/journal.pone.0133986
PMCID: PMC4519248

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A TALEN-Exon Skipping Design for a Bethlem Myopathy Model in Zebrafish.PMID 26221953Read ↗

Zebrafish models of collagen VI-related myopathiesSemantic proximity Read ↗

Rewiring Fibroblast–Muscle Axis Drives Progressive Pathology in Bethlem MyopathySemantic proximity Read ↗

A Titin Knock-in model for Hereditary Myopathy with Early Respiratory FailureSemantic proximity Read ↗

In vivo characterization of human myofibrillar myopathy genes in zebrafish.Semantic proximity Read ↗

Knock-in Mouse Model of Hereditary Myopathy with Early Respiratory Failure Carrying the Titin Variant Corresponding to Human p.N31786KSemantic proximity Read ↗

In Search of a Target Gene for a Desirable Phenotype in Aquaculture: Genome Editing of Cyprinidae and Salmonidae Species.Semantic proximity Read ↗

An <i>in vivo</i> approach to characterize novel variants associated with musculoskeletal disordersSemantic proximity Read ↗

Exon- and contraction-dependent functions of titin in sarcomere assembly.Semantic proximity Read ↗

Zebrafish Models for Skeletal and Extraskeletal Osteogenesis Imperfecta Features: Unveiling Pathophysiology and Paving the Way for Drug DiscoverySemantic proximity Read ↗

Muscular dystrophy modeling in zebrafish.Semantic proximity Read ↗

A modifier screen identifies DNAJB6 as a cardiomyopathy susceptibility geneSemantic proximity Read ↗

An updated <i>C. elegans</i> nuclear body muscle transcriptome for studies in muscle formation and functionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.