Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Acetylation of aldehyde dehydrogenase ALDH1L2 regulates cellular redox balance and the chemosensitivity of colorectal cancer to 5-fluorouracil.

The Journal of biological chemistry - 1 Sept 2023

Li Chaoqun, Teng Peng, Sun Shengbai, Cui Kaisa, Yao Surui, Fei Bojian, Ling Feng, Huang Zhaohui

Abstract excerpt

Folate-mediated one-carbon metabolism (FOCM) is crucial in sustaining rapid proliferation and survival of cancer cells. The folate cycle depends on a series of key cellular enzymes, including aldehyde dehydrogenase 1 family member L2 (ALDH1L2) that is usually overexpressed in cancer cells, but the regulatory mechanism of ALDH1L2 remains undefined. In this study, we observed the significant overexpression of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acetylation
Share to Drug Resistance, Neoplasm

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fluorouracil

Share to Folic Acid

Share to Oxidation-Reduction

Share to Oxidoreductases Acting on CH-NH Group Donors

Share to Sirtuin 3

Share to Up-Regulation

Source

Open in PubMed Open full text

Identifiers

PMID: 37507016
DOI: 10.1016/j.jbc.2023.105090
PMCID: PMC10470206

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Acetylation of aldehyde dehydrogenase ALDH1L2 regulates cellular redox balance and the chemosensitivity of colorectal cancer to 5-fluorouracil.PMID 37507016Read ↗

Deacetylation of MTHFD2 by SIRT4 senses stress signal to inhibit cancer cell growth by remodeling folate metabolismSemantic proximity Read ↗

TNFα-induced IDH1 hyperacetylation reprograms redox homeostasis and promotes the chemotherapeutic sensitivity.Semantic proximity Read ↗

Mitochondrial Sirtuins in Chronic Degenerative Diseases: New Metabolic Targets in Colorectal CancerSemantic proximity Read ↗

The importance of mitochondrial folate enzymes in human colorectal cancerSemantic proximity Read ↗

Deacetylation of serine hydroxymethyl-transferase 2 by SIRT3 promotes colorectal carcinogenesisSemantic proximity Read ↗

GCDH Acetylation Orchestrates DNA Damage Response and Autophagy via Mitochondrial ROS to Suppress Hepatocellular Carcinoma ProgressionSemantic proximity Read ↗

Histone acetylation and chemoresistance in colorectal cancer : an opportunity for effective personalized treatmentSemantic proximity Read ↗

Exosomal IDH1 increases the resistance of colorectal cancer cells to 5-FluorouracilSemantic proximity Read ↗

Targeting a Sirt5-Positive Subpopulation Overcomes Multidrug Resistance in Wild-Type Kras Colorectal CarcinomasSemantic proximity Read ↗

Lysine acetylation restricts mutant IDH2 activity to optimize transformation in AML cells.Semantic proximity Read ↗

Histone lactylation promotes multidrug resistance in hepatocellular carcinoma by forming a positive feedback loop with PTENSemantic proximity Read ↗

SPARC Promotes Aerobic Glycolysis and 5‐Fluorouracil Resistance in Colorectal Cancer Through the STAT3 / HK2 AxisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.