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Article

Growth factor and co-receptor release by structural regulation of substrate metalloprotease accessibility.

Scientific reports - 23 Nov 2016

Parra Liseth M, Hartmann Monika, Schubach Salome, Ma Junzhi, Herrlich Peter, Herrlich Andreas

Abstract excerpt

Release of cytokines, growth factors and other life-essential molecules from precursors by a-disintegrin-and-metalloproteases (ADAMs) is regulated with high substrate-specificity. We hypothesized that this is achieved by cleavage-regulatory intracellular-domain (ICD)-modifications of the precursors. We show here that cleavage-stimuli-induced specific ICD-modifications cause structural substrate changes that...

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Identifiers

PMID: 27876763
DOI: 10.1038/srep37464
PMCID: PMC5120278

Genes

NRG1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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