Article
BLM germline and somatic PKMYT1 and AHCY mutations: Genetic variations beyond MYCN and prognosis in neuroblastoma.
Medical hypotheses - 1 Dec 2016
Novak E M, Halley N S, Gimenez T M, Rangel-Santos A, Azambuja A M P, Brumatti M, Pereira P L, Vince C S C, Giorgi R R, Bendit I, Cristofani L M, Odone-Filho V
Abstract excerpt
Neuroblastoma (NB) is the most common extra cranial solid tumor of childhood and often lethal in childhood. Clinical and biologic characteristics that are independently prognostic of outcome in NB are currently used for risk stratification to optimally the therapy. It includes age at diagnosis, International Neuroblastoma Staging System tumor histopathology and MYCN amplification. However, even in patients with...
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