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Article

Detection of Targetable Genetic Abnormalities in Neuroblastoma Circulating Tumour DNA.

International journal of molecular sciences - 27 Sept 2025

Danilenko Marina, Nath Sharanya, Baines Jack, Gordon Freya, Merugu Swathi, Allinson Lisa M, Potts Aaron, Collins Bethany, Goodman Angharad, Kidman Samuel E, McAnulty Ciaron, Jamieson David, Tweddle Deborah A

Abstract excerpt

Neuroblastoma (NB) is an aggressive childhood cancer requiring intensive multimodal therapies in high-risk (HRNB) patients. Currently, invasive surgical biopsies are required to classify NB risk group and assign treatment based on the tumour genetic profile. Circulating tumour DNA (ctDNA) obtained from blood samples can be used to identify tumour biomarkers. Here we applied targeted next-generation sequencing...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 41096734
DOI: 10.3390/ijms26199466
PMCID: PMC12524965

Genes

ALK
PTPN11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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