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Article

Noncanonical Wnt Signaling Promotes Myofibroblast Differentiation in Pulmonary Fibrosis

9 Jun 2021

Abstract excerpt

Abstract The Wnt/β-catenin pathway initiates a signaling cascade that is critical in cell differentiation and the normal development of multiple organ systems. The reactivation of this pathway has been documented in experimental and human idiopathic pulmonary fibrosis, wherein Wnt/β-catenin activation has been implicated in epithelial-cell repair. Furthermore, the canonical ligand Wnt3a is known to induce...

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Share to Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
Share to Wnt/β-catenin signaling in development and cancer

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PMID: 34107237
DOI: 10.1165/rcmb.2020-0499oc

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