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Article

Jun N-terminal kinase 1 regulates epithelial-to-mesenchymal transition induced by TGF-β1

11 Mar 2008

Abstract excerpt

Transforming growth factor beta1 (TGF-beta1) is a cardinal cytokine in the pathogenesis of airway remodeling, and promotes epithelial-to-mesenchymal transition (EMT). As a molecular interaction between TGF-beta1 and Jun N-terminal kinase (JNK) has been demonstrated, the goal of this study was to elucidate whether JNK plays a role in TGF-beta1-induced EMT. Primary cultures of mouse tracheal epithelial cells (MTEC)...

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PMID: 18334556
DOI: 10.1242/jcs.019455

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