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Article

Association of tryptophan hydroxylase-2 polymorphisms with oppositional defiant disorder in a Chinese Han population.

Behavioral and brain functions : BBF - 21 Nov 2016

Wang Chang-Hong, Liu Cong, Cong En-Zhao, Xu Gai-Ling, Lv Ting-Ting, Zhang Ying-Li, Ning Qiu-Fen, Wang Ji-Kang, Nie Hui-Yao, Li Yan

Abstract excerpt

BACKGROUND: Oppositional defiant disorder (ODD) is a behavioral disorder of school-age population. It is well known that 5-HT dysfunction is correlated with impulsivity, which is one of the common characteristics of ODD. The enzyme tryptophan hydroxylase-2 (TPH-2) synthesizes 5-HT in serotonergic neurons of the midbrain raphe. The purposes of this study were to investigate the potential association of TPH-2...

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Identifiers

PMID: 27871272
DOI: 10.1186/s12993-016-0113-0
PMCID: PMC5117514

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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