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Article

A Viral Deamidase Targets the Helicase Domain of RIG-I to Block RNA-Induced Activation.

Cell host & microbe - 14 Dec 2016

Zhao Jun, Zeng Yi, Xu Simin, Chen Jie, Shen Guobo, Yu Caiqun, Knipe David, Yuan Weiming, Peng Jian, Xu Wenqing, Zhang Chao, Xia Zanxian, Feng Pinghui

Abstract excerpt

RIG-I detects double-stranded RNA (dsRNA) to trigger antiviral cytokine production. Protein deamidation is emerging as a post-translational modification that chiefly regulates protein function. We report here that UL37 of herpes simplex virus 1 (HSV-1) is a protein deamidase that targets RIG-I to block RNA-induced activation. Mass spectrometry analysis identified two asparagine residues in the helicase 2i domain...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27866900
DOI: 10.1016/j.chom.2016.10.011
PMCID: PMC5159239

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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